{"product_id":"entresto-sacubitril-valsartan","title":"ENTRESTO (Sacubitril\/Valsartan)","description":"\u003ch5\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat is this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eSacubitril+Valsartan, Entresto\u003c\/strong\u003e\u003cbr\u003eAngiotensin II Receptor Blocker;\u003c\/span\u003e\u003cspan\u003e Neprilysin Inhibitor\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eEntresto is indicated for use in heart failure.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e“Alert: Black Box Warning\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFetal toxicity:\u003cbr\u003e\u003c\/b\u003eDrugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. When pregnancy is detected, discontinue valsartan as soon as possible.”\u003c\/p\u003e\n\u003ch5\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow does this medication work? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan data-mce-fragment=\"1\"\u003eSacubitril+Valsartan, Entresto works through two distinct mechanisms of action.  Valsartan blocks the action of angiotensin II which acts as a vasoconstrictor and activator of aldosterone release.  Hence, the displacement of angiotensin II by Valsartan is responsible for its blood pressure lowering effect.  Sacubitril is a prodrug that inhibits neprilysin (neutral endopeptidase) through the active metabolite LBQ657, leading to increased levels of peptides, including natriuretic peptides; induces vasodilation and natriuresis.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003ci\u003eOral:\u003c\/i\u003e Take twice daily\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan data-mce-fragment=\"1\"\u003eTake with or without food.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan data-mce-fragment=\"1\"\u003eBefore starting Sacubitril+Valsartan, Entresto make sure your physician is aware of any allergies or medications you currently take.  As with any other angiotensin II receptor antagonist, there is are risks of hyperkalemia, hypotension, deterioration in renal function.  Valsartan should be used with caution in patients who have ascites, heart failure, hepatic and renal impairment, and renal artery stenosis.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan data-mce-fragment=\"1\"\u003eIf you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eDizziness, hypotension, orthostatic hypotension, fatigue, headache, hyperkalemia, diarrhea, abdominal pain, nausea, joint pain, dry cough.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNote this is not a complete list of side effects for \u003c\/span\u003e\u003cspan\u003eSacubitril+Valsartan, Entresto\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eo\u003c\/span\u003e\u003cspan\u003enly common ones.\u003c\/span\u003e\u003c\/p\u003e","brand":"NOVARTIS PHARMACEUTICALS","offers":[{"title":"24.3\/25.7mg - 30 Tab - Canada","offer_id":47133885038910,"sku":null,"price":456.0,"currency_code":"USD","in_stock":true},{"title":"48.6\/51.4mg - 60 Tab - Canada","offer_id":47133885137214,"sku":null,"price":456.0,"currency_code":"USD","in_stock":true},{"title":"97.2\/102.8mg - 60 Tab - Canada","offer_id":47133885202750,"sku":null,"price":456.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Entresto24-26mg.jpg?v=1695126374","url":"https:\/\/www.advochealth.com\/products\/entresto-sacubitril-valsartan","provider":"AdvocHealth","version":"1.0","type":"link"}