{"product_id":"farxiga-forxiga-dapagliflozin","title":"FARXIGA\/FORXIGA (Dapagliflozin)","description":"\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eFARXIGA\/FORXIGA (Dapagliflozin)\u003c\/strong\u003e\u003cbr\u003eAntidiabetic Agent; Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #ff6737;\"\u003eBrand Name US: Farxiga\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"color: #ff6737;\"\u003eCanadian Equivalent: Forxiga\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDapagliflozin is indicated for Diabetes mellitus type 2 and as an adjunctive therapy for the treatment of heart failure with reduced ejection fraction.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow does this medication work? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003eSGLT2 is in the proximal renal tubules of the nephron (a functional unit of the kidney) and is the main site of reabsorption of filtered glucose.  FARXIGA\/FORXIGA (Dapagliflozin) inhibits this transporter which lowers glucose reabsorption and lowers the renal threshold for glucose resulting in its urinary excretion thereby lowering plasma glucose concentrations.  It also reduces sodium reabsorption and increases sodium delivery to the distal tubule which may decrease cardiac preload\/afterload and downregulate sympathetic activity.\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cem\u003eOral:\u003c\/em\u003e Take 5-10mg once daily.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eHow to Take:\u003c\/b\u003e\u003cspan\u003e Follow instructions provided by physician\/pharmacy label, take consistently at same time each day usually in the morning due to diuretic effect unless otherwise directed.  Monitor blood pressure when initiating due to diuretic effect.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eNote: Do not skip standard diabetic foot care regimen.  Must monitor for wounds or signs of new infection, ulcers, sores or new pain or tenderness.  A trial involving a similar medication (Canagliflozin) showed a higher frequency of lower limb amputations compared to placebo so caution must be taken.  There is no direct evidence of dapagliflozin having this effect but due to similarities it should be taken seriously.  Avoid volume depletion or dehydration due to diuretic effect of this medication.\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003eBefore starting FARXIGA\/FORXIGA (Dapagliflozin), make sure your physician is aware of any allergies, medications you currently take, if you have kidney disease, a history of diabetic ketoacidosis, have had bariatric surgery, are pregnant, or breastfeeding.\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"font-weight: 400;\" data-mce-fragment=\"1\" data-mce-style=\"font-weight: 400;\"\u003eIf you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"font-weight: 400;\" data-mce-fragment=\"1\" data-mce-style=\"font-weight: 400;\"\u003eKeep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eUrinary tract infection (due to sugar content in urine – more common in females due to shorter urethra), increased urine output, genitourinary fungal infection (more common in females), nasopharyngitis, back pain, influenza, dyslipidemia, nausea, thirst.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNote this is not a complete list of side effects for FARXIGA\/FORXIGA (Dapagliflozin), only common ones.\u003c\/span\u003e\u003c\/p\u003e","brand":"ASTRAZENECA","offers":[{"title":"5mg - 30 Tab - Canada","offer_id":47134803493182,"sku":null,"price":385.0,"currency_code":"USD","in_stock":true},{"title":"10mg - 30 Tab - Canada","offer_id":47134803525950,"sku":null,"price":385.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Farxiga5mg.jpg?v=1695130715","url":"https:\/\/www.advochealth.com\/products\/farxiga-forxiga-dapagliflozin","provider":"AdvocHealth","version":"1.0","type":"link"}