{"product_id":"fasenra-benralizumab","title":"FASENRA (Benralizumab)","description":"\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong\u003eFASENRA (Benralizumab)\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eAnti-Asthmatic, Interleukin-5 Receptor Antagonist\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eFASENRA (Benralizumab) is indicated for the treatment of severe asthma.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the ingredients in this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eFASENRA\u003c\/strong\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cem\u003e\u003cbr\u003eMedicinal ingredient:\u003c\/em\u003e\u003c\/span\u003e \u003cbr\u003eBenralizumab\u003cbr\u003e\u003c\/span\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cem\u003eNon-medicinal ingredients:\u003c\/em\u003e\u003c\/span\u003e\u003cstrong\u003e\u003cbr\u003e\u003c\/strong\u003e\u003cspan style=\"font-weight: 400;\"\u003eL-histidine, L-histidine hydrochloride monohydrate, α,α-trehalose dihydrate, polysorbate 20 and water. Preservative-Free.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow does this medication work? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eFASENRA (Benralizumab) is a monoclonal \u003c\/span\u003e\u003cspan\u003emonoclonal antibody (IgG1, kappa) that binds to the alpha subunit of the interleukin-5 receptor. IL-5 is the major cytokine responsible for the growth and differentiation, recruitment, activation, and survival of eosinophils (a cell type associated with inflammation and an important component in the pathogenesis of asthma). Benralizumab by inhibiting IL-5 signaling, reduces the production and survival of eosinophils and basophils through antibody dependent cell-mediated cytotoxicity.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003e\u003cem\u003eSQ:\u003c\/em\u003e Inject 30mg subcutaneously every 4 weeks for the first 3 doses, then once every 8 weeks.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003e\u003cstrong\u003eHow to Take:  \u003c\/strong\u003ePrior to administration, allow syringe\/autoinjector to warm at room temperature for ~30 minutes.  Administer the subcutaneous injection into the upper arm, thigh, or abdomen. Prefilled syringe should only be administered by a health care provider; autoinjector may be administered by patient or caregiver after proper training. Refer to the manufacturer’s labeling for additional administration instructions.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eBefore starting FASENRA (Benralizumab)\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003emake sure your physician is aware of any allergies or medications you currently take. Benralizumab should never be used for acute asthmatic symptoms or exacerbations.  Do not abruptly discontinue corticosteroids when initiating Benralizumab as they should be tapered off gradually if appropriate.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan\u003eWhat size needle does this medication use?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eFASENRA\u003c\/strong\u003e\u003cbr\u003ePrefilled syringe: \u003cspan style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\" data-mce-fragment=\"1\"\u003e29-gauge, 12.7 mm needle\u003c\/span\u003e\u003cbr\u003eAutoinjector: \u003cspan style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\" data-mce-fragment=\"1\"\u003e29-gauge, 12.7 mm needle\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cspan\u003e\u003cspan style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\" data-mce-fragment=\"1\"\u003eWhat is the difference between a prefilled syringe and an autoinjector?\u003c\/span\u003e\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003e\u003cspan style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\" data-mce-fragment=\"1\"\u003eBoth an autoinjector device and prefilled syringe are comparable with respect to ease of use, tolerability, and efficacy.  However the addition of an autoinjector to deliver a prefilled syringe can enhance patient safety.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIf a dose is missed or you are unable to keep an appointment for one of the injections, the missed dose should be administered as soon as possible.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\" data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times. Store in a refrigerator (2°C - 8°C). FASENRA (Benralizumab) may be kept at room temperature up to 25°C for a maximum of 14 days. After removal from the refrigerator, \u003cspan data-mce-fragment=\"1\"\u003eBenralizumab must be \u003c\/span\u003eused within 14 days or discarded. Store in the original package in order to protect from light. Do not freeze or expose to heat. Discard unused drug into sharps container. Do not use this medicine after the expiry date that is stated on the label.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eAntibody development, headache, pharyngitis, fever.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNote this is not a complete list of side effects for FASENRA (Benralizumab),\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eonly common ones.\u003c\/span\u003e\u003c\/p\u003e","brand":"ASTRAZENECA","offers":[{"title":"30mg\/ml - 1ml Autoinjector - Canada","offer_id":47134809915710,"sku":null,"price":4550.0,"currency_code":"USD","in_stock":true},{"title":"30mg\/ml - 1ml Prefilled Syringe - Canada","offer_id":47134809948478,"sku":null,"price":4900.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Fasenraautoinjector.jpg?v=1695130738","url":"https:\/\/www.advochealth.com\/products\/fasenra-benralizumab","provider":"AdvocHealth","version":"1.0","type":"link"}