{"product_id":"genvoya-elvitegravir-cobicistat-emtricitabine-tenofovir-alafenamide","title":"GENVOYA (Elvitegravir\/Cobicistat\/ Emtricitabine\/Tenofovir Alafenamide)","description":"\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cstrong\u003eGENVOYA (Elvitegravir\/Cobicistat\/ Emtricitabine\/Tenofovir Alafenamide)\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan class=\"list-set-name\" data-mce-fragment=\"1\"\u003eAntiretroviral, Integrase Inhibitor (Anti-HIV)\u003c\/span\u003e;\u003cspan class=\"list-set-name\" data-mce-fragment=\"1\"\u003e Reverse Transcriptase Inhibitor, Nucleoside (Anti-HIV)\u003c\/span\u003e; \u003cspan class=\"list-set-name\" data-mce-fragment=\"1\"\u003eCytochrome P-450 Inhibitor\u003c\/span\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eGENVOYA, a combination of Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide is officially indicated for the treatment of \u003c\/span\u003e\u003cspan class=\"condition\"\u003e\u003cspan class=\"content\"\u003eHIV-1 infection.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow does this medication work? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003eElvitegravir is an HIV-1 integrase strand transfer inhibitor (INSTI). Integrase is an HIV-1 encoded enzyme that is required for viral replication. Inhibition of integrase prevents the integration of HIV-1 DNA into host genomic DNA, blocking the formation of the HIV1 provirus and propagation of the viral infection. Elvitegravir does not inhibit human topoisomerases I or II.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eCobicistat is a selective, mechanism-based inhibitor of cytochromes P450 of the CYP3A subfamily. Inhibition of CYP3A-mediated metabolism by cobicistat enhances the systemic exposure of CYP3A substrates, such as elvitegravir, where bioavailability is limited and half-life is shortened by CYP3A-dependent metabolism.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eEmtricitabine is a nucleoside analogue of 2’-deoxycytidine. Emtricitabine is phosphorylated by cellular enzymes to form emtricitabine triphosphate. Emtricitabine triphosphate inhibits HIV replication through incorporation into viral DNA by the HIV reverse transcriptase, which results in DNA chain-termination. Emtricitabine has activity that is specific to human immunodeficiency virus (HIV-1 and HIV-2) and hepatitis B virus. Emtricitabine triphosphate is a weak inhibitor of mammalian DNA polymerases that include mitochondrial DNA polymerase γ and there was no evidence of toxicity to mitochondria in vitro and in vivo.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eTenofovir Alafenamide is a phosphonamidate prodrug of tenofovir (2’-deoxyadenosine monophosphate analogue) and differs from tenofovir disoproxil fumarate which is another prodrug of tenofovir. Tenofovir alafenamide is permeable into cells and due to increased plasma stability, and intracellular activation through hydrolysis by cathepsin A, \u003cspan data-mce-fragment=\"1\"\u003eTenofovir \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003eA\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003elafenamide\u003c\/span\u003e is efficient in loading Tenofovir into peripheral blood mononuclear cells (PBMCs) (including lymphocytes and other HIV target cells) and macrophages. Intracellular tenofovir is subsequently phosphorylated to the pharmacologically active metabolite tenofovir diphosphate. Tenofovir diphosphate inhibits HIV replication through incorporation into viral DNA by the HIV reverse transcriptase, which results in DNA chain-termination. Tenofovir has activity that is specific to human immunodeficiency virus (HIV-1 and HIV2). \u003cspan data-mce-fragment=\"1\"\u003eTenofovir \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003eA\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003elafenamide\u003c\/span\u003e displayed antiviral activity in cell culture against all HIV-1 groups. Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases that include mitochondrial DNA polymerase γ. In the in vitro study, \u003cspan data-mce-fragment=\"1\"\u003eTenofovir \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003eA\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003elafenamide\u003c\/span\u003e did not significantly affect mitochondrial DNA in HepG2 cells.\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cem\u003eOral:\u003c\/em\u003e Take 1\u003cspan data-mce-fragment=\"1\"\u003e tablet (elvitegravir 150mg\/cobicistat 150mg\/emtricitabine 200mg\/tenofovir alafenamide 10mg) once daily.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cb data-mce-fragment=\"1\"\u003eHow to Take:\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003c\/b\u003e\u003cspan data-mce-fragment=\"1\"\u003eTake with food.\u003c\/span\u003e \u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eBefore starting GENVOYA (Elvitegravir\/Cobicistat\/Emtricitabine\/Tenofovir Alafenamide), make sure your physician is aware of any allergies or medications you currently take\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e, if you have chronic hepatitis B, i\u003c\/span\u003emmune reconstitution syndrome\u003cspan data-mce-fragment=\"1\"\u003e, or renal toxicity. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003eIf you miss a dose of GENVOYA (Elvitegravir\/Cobicistat\/Emtricitabine\/Tenofovir Alafenamide) within 18 hours of the time it is usually taken, take the missed dose with food as soon as possible, and then take the next dose at the regularly scheduled time. If the dose is missed by more than 18 hours, do not take the missed dose, but resume the usual dosing schedule.\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cdiv class=\"sect level-2\"\u003e\n\u003cp\u003e\u003cspan class=\"condition\"\u003e\u003cspan class=\"content\"\u003eHeadache\u003c\/span\u003e\u003c\/span\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"condition\"\u003e\u003cspan class=\"content\"\u003efatigue, i\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"condition\"\u003e\u003cspan class=\"content\"\u003encreased serum cholesterol, d\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"condition\"\u003e\u003cspan class=\"content\"\u003eiarrhea, h\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"condition\"\u003e\u003cspan class=\"content\"\u003eematuria, i\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"condition\"\u003e\u003cspan class=\"content\"\u003encreased serum alanine aminotransferase\u003c\/span\u003e\u003c\/span\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"condition\"\u003e\u003cspan class=\"content\"\u003eincreased serum amylase\u003c\/span\u003e\u003c\/span\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"condition\"\u003e\u003cspan class=\"content\"\u003eincreased serum aspartate aminotransferase.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"condition\"\u003e\u003cspan class=\"content\"\u003eNote this is not a complete list of side effects for GENVOYA (Elvitegravir\/Cobicistat\/Emtricitabine\/Tenofovir Alafenamide), only common ones.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"GILEAD SCIENCES","offers":[{"title":"150\/150\/200\/10mg - 30 Tab - Canada","offer_id":47135120752958,"sku":null,"price":2618.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Genvoya.jpg?v=1695131753","url":"https:\/\/www.advochealth.com\/products\/genvoya-elvitegravir-cobicistat-emtricitabine-tenofovir-alafenamide","provider":"AdvocHealth","version":"1.0","type":"link"}