{"product_id":"januvia-sitagliptin","title":"JANUVIA (Sitagliptin)","description":"\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cstrong\u003eJANUVIA (Sitagliptin)\u003c\/strong\u003e\u003cbr\u003eAntidiabetic Agent; Dipeptidyl Peptidase 4 (DPP-4) Inhibitor\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eJANUVIA (Sitagliptin) is officially indicated for Diabetes mellitus type 2 as an adjunct to diet and exercise.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow does this medication work? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eJANUVIA (Sitagliptin) is a DPP-4 inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones.  Concentrations of the active intact hormones are increased by \u003cspan data-mce-fragment=\"1\"\u003eSitagliptin\u003c\/span\u003e, thereby increasing and prolonging the action of these hormones. Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day.  Incretin hormones such as glucagon-like peptide-1 (GLP-1) regulate glucose by increasing the production and release of insulin from pancreatic beta cells while also decreasing glucagon secretion from pancreatic alpha cells.  Decreasing glucagon results in less glucose production by the liver.  By increasing and prolonging active incretin levels, \u003cspan data-mce-fragment=\"1\"\u003eSitagliptin\u003c\/span\u003e increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cem\u003eOral:\u003c\/em\u003e Take 100mg once daily.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eHow to Take:\u003c\/b\u003e\u003cspan\u003e \u003cspan style=\"font-weight: 400;\" data-mce-fragment=\"1\" data-mce-style=\"font-weight: 400;\"\u003eTake consistently at same time each day with or without a meal unless otherwise directed.  Swallow the tablets whole, never split, crush or chew.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBefore starting JANUVIA (Sitagliptin), make sure your physician is aware of any allergies, medications you currently take, if you have had bariatric surgery, if you have kidney disease, cardiovascular disease, a history of pancreatitis, are pregnant, or breastfeeding.  There have been reports of acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis. If pancreatitis is suspected, promptly discontinue \u003cspan data-mce-fragment=\"1\"\u003eSitagliptin\u003c\/span\u003e.  Dosage adjustment is recommended in patients with moderate or severe renal insufficiency and in patients with ESRD.  Assessment of renal function is recommended prior to initiating \u003cspan data-mce-fragment=\"1\"\u003eSitagliptin\u003c\/span\u003e and periodically thereafter.  There is an increased risk of hypoglycemia when \u003cspan data-mce-fragment=\"1\"\u003eSitagliptin\u003c\/span\u003e is added to an insulin secretagogue or insulin therapy. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"font-weight: 400;\" data-mce-fragment=\"1\" data-mce-style=\"font-weight: 400;\"\u003eIf you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"font-weight: 400;\" data-mce-fragment=\"1\" data-mce-style=\"font-weight: 400;\"\u003eKeep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eUpper respiratory tract infection, nasopharyngitis and headache.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eNote this is not a complete list of side effects for JANUVIA (Sitagliptin), only common ones.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"MERCK","offers":[{"title":"25mg - 30 Tab - Canada","offer_id":47135901024574,"sku":null,"price":378.0,"currency_code":"USD","in_stock":true},{"title":"50mg - 30 Tab - Canada","offer_id":47135901057342,"sku":null,"price":378.0,"currency_code":"USD","in_stock":true},{"title":"100mg - 30 Tab - Canada","offer_id":47135901090110,"sku":null,"price":378.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Januvia25mg.jpg?v=1695134475","url":"https:\/\/www.advochealth.com\/products\/januvia-sitagliptin","provider":"AdvocHealth","version":"1.0","type":"link"}