{"product_id":"lysodren-mitotane","title":"LYSODREN (Mitotane)","description":"\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cb\u003eLYSODREN (Mitotane)\u003cbr\u003e\u003c\/b\u003e\u003cspan\u003eAntineoplastic Agent, Miscellaneous\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eLYSODREN (Mitotane) is indicated for treatment of adrenocortical carcinoma.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eALERT: WARNING\u003cbr\u003e\u003c\/b\u003e\u003cspan\u003eIn patients taking mitotane, adrenal crisis occurs in the setting of shock or severe trauma and response to shock is impaired. Administer hydrocortisone, monitor for escalating signs of shock, and discontinue mitotane until recovery occurs.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow does this medication work?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eLYSODREN (Mitotane) is an adrenolytic agent that directly suppresses the adrenal cortex and alters the metabolism of steroids in the periphery.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003ci\u003e\u003cspan\u003eOral: \u003c\/span\u003e\u003c\/i\u003eTake \u003cspan\u003e2 to 6 g per day in 3 to 4 divided doses initially, then increase incrementally to achieve a blood concentration of 14 to 20 mcg\/mL or as tolerated.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eHow to Take:\u003c\/b\u003e\u003cspan\u003e Follow instructions provided by physician\/pharmacy label, take consistently at same times each day unless otherwise directed. Mitotane is associated with a moderate emetic potential so antiemetics may be needed to prevent nausea and vomiting.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eYou Need to Avoid:\u003c\/b\u003e\u003cspan\u003e  \u003c\/span\u003e\u003cspan\u003eSignificant drug interactions exist, requiring dose\/frequency adjustment or avoidance so avoid starting any new medications without consulting prescriber.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eBefore starting LYSODREN (Mitotane), make sure your physician is aware of any allergies or medications you currently take, if you have hepatic impairment, are pregnant, or breastfeeding. Mitotane use has been associated with rare but serious adverse events such as adrenal crisis, adrenal insufficiency, CNS toxicity, gastrointestinal toxicity, ovarian macrocysts, prolonged bleeding time, and thyroid dysfunction.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eIf you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eSkin rash, anorexia, diarrhea, nausea, vomiting, depression, dizziness, vertigo.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNote this is not a complete list of side effects for LYSODREN (Mitotane), only common ones.\u003c\/span\u003e\u003c\/p\u003e","brand":"BRISTOL-MYERS SQUIBB","offers":[{"title":"500mg - 100 Tab - Canada -  SPECIAL ORDER","offer_id":47138720481598,"sku":null,"price":910.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Lysodren.jpg?v=1695148792","url":"https:\/\/www.advochealth.com\/products\/lysodren-mitotane","provider":"AdvocHealth","version":"1.0","type":"link"}