{"product_id":"mayzent-siponimod","title":"MAYZENT (Siponimod)","description":"\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cb\u003eMAYZENT (Siponimod)\u003cbr\u003e\u003c\/b\u003e\u003cspan\u003eSphingosine 1-Phosphate (S1P) Receptor Modulator\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eMAYZENT (Siponimod) \u003cspan style=\"font-weight: 400;\" data-mce-fragment=\"1\" data-mce-style=\"font-weight: 400;\"\u003eis a sphingosine 1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow does this medication work? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eMAYZENT (Siponimod) is \u003c\/span\u003e\u003cspan\u003ea sphingosine-1-phosphate (S1P) receptor modulator that binds to sphingosine 1-phosphate receptors 1 and 5.  This inhibits lymphocyte release from lymph nodes, thereby decreasing the number of lymphocytes available to the CNS which reduces central inflammation.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003ci\u003e\u003cspan\u003eOral: CYP2C9 Genotype *1\/*1, *1\/*2, or *2\/*2:\u003c\/span\u003e\u003c\/i\u003e\u003cspan\u003e Take 0.25 mg once daily on Days 1 and 2, then 0.5 mg once daily on Day 3, then 0.75 mg once daily on Day 4, then 1.25 mg once daily on Day 5 then maintain on 2mg once daily Day 6 and on.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003e\u003cspan\u003eOral: CYP2C9 Genotype *1\/*3 or *2\/*3:\u003c\/span\u003e\u003c\/i\u003e\u003cspan\u003e Take 0.25 mg once daily on Days 1 and 2, then 0.5 mg once daily on Day 3, then 0.75 mg once daily on Day 4 then maintain on 1mg once daily Day 5 and on.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eHow to Take:\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eAdminister with or without food. Swallow tablets whole; do not chew, crush, or split. \u003c\/span\u003e\u003cspan\u003eCases of rebound syndrome (clinical and radiological signs of severe exacerbation beyond what was expected) have been reported with discontinuation of another sphingosine 1-phosphate receptor modulator. Monitor for development of severe increase in disability following discontinuation and begin appropriate treatment as needed. Avoid immunization with live attenuated vaccines during and for 4 weeks after treatment. Vaccines may not be as effective if administered during therapy; discontinuation of treatment 1 week before and 4 weeks following a planned vaccination is recommended.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eNote: \u003cspan\u003eSignificant drug interactions exist, requiring dose\/frequency adjustment or avoidance so avoid starting any new medications without consulting prescriber.\u003c\/span\u003e\u003cspan\u003e  Avoid missing dosages. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eBefore starting MAYZENT (Siponimod), make sure your physician is aware of any allergies or medications you currently take, if you have cardiovascular disease, hepatic impairment, \u003c\/span\u003e\u003cspan\u003eCYP2C9*3\/*3 genotype, if you are immunocompromised, have an active infection, active malignancy,\u003c\/span\u003e\u003cspan\u003e are pregnant, or breastfeeding. Siponimod use has been associated with rare but serious adverse events such as atrioventricular conduction delays, bradycardia, hepatic effects, hypertension, increased risk of infection, macular edema, malignancy, neurotoxicity, progressive multifocal leukoencephalopathy, QT prolongation, and reduced respiratory function.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eIf a dose is missed for more than 24 hours during the initial titration regimen, reinitiate with Day 1 of the titration regimen. If treatment with Siponimod is interrupted for 4 or more consecutive daily doses after completion of initial titration, reinitiate treatment with Day 1 of the titration regimen, including first-dose monitoring when appropriate. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times. Store unopened containers in a refrigerator between 2°C to 8°C (36°F to 46°F); may be stored at 20°C to 25°C (68°F to 77°F) for ≤3 months after dispensing to the patient. Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eHypertension, headache, falling, increased serum transaminases, peripheral edema, bradycardia, first degree atrioventricular block, dizziness, nausea, diarrhea, increased serum bilirubin, increased serum alanine aminotransferase, limb pain.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNote this is not a complete list of side effects for MAYZENT (Siponimod), only common ones.\u003c\/span\u003e\u003c\/p\u003e","brand":"NOVARTIS PHARMACEUTICALS","offers":[{"title":"0.25mg - 120 Tab - Canada","offer_id":47138719957310,"sku":null,"price":6790.0,"currency_code":"USD","in_stock":true},{"title":"2mg - 28 Tab - Canada","offer_id":47138719990078,"sku":null,"price":6370.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Mayzent0.25mg.jpg?v=1695148790","url":"https:\/\/www.advochealth.com\/products\/mayzent-siponimod","provider":"AdvocHealth","version":"1.0","type":"link"}