{"product_id":"mektovi-binimetinib","title":"MEKTOVI (Binimetinib)","description":"\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #000000;\" data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cb\u003eMEKTOVI (Binimetinib)\u003c\/b\u003e\u003cbr\u003eAntifungal Agent\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\"\u003eMEKTOVI (Binimetinib) is a kinase inhibitor that inhibits mitogen-activated extracellular kinase (MEK) 1 and 2 activation and kinase activity.  MEKTOVI (Binimetinib) in combination with encorafenib is used in the treatment of unresectable or metastatic melanoma with a BRAF V600E or V600K mutation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cb\u003eALERT: WARNING\u003cbr\u003e\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\"\u003eMEKTOVI (Binimetinib) can cause serious organ toxicities and must be dosed with caution. Retinopathy, retinal vein occlusion (RVO) and uveitis can occur and patients should be regularly assessed by an ophthalmologist for any visual disturbances. Patients should be assessed for new or progressive unexplained pulmonary symptoms or findings for possible interstitial lung disease.  Hepatotoxicity has been reported with MEKTOVI (Binimetinib), liver function tests should be done before and during treatment. Monitor creatine phosphokinase and creatinine periodically for signs of rhabdomyolysis.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\"\u003eAdvise females with reproductive potential of potential risk to the fetus and to use effective contraception while on MEKTOVI (Binimetinib).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #000000;\" data-mce-fragment=\"1\"\u003eHow does this medication work? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\"\u003eMEKTOVI (Binimetinib) \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\"\u003ereversibly inhibits mitogen-activated extracellular kinase (MEK) 1 and 2 activation and kinase activity. MEK proteins are upstream regulators of the extracellular signal-related kinase (ERK) pathway. Binimetinib inhibits ERK phosphorylation and viability and MEK-dependent phosphorylation of the protein kinase B-raf (BRAF) mutant cell lines. The combination of binimetinib and encorafenib allows for greater antitumor activity in BRAF V600 mutant cell lines; in animal studies, the combination also delayed the emergence of resistance in BRAF V600E mutant cells compared to either drug alone.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #000000;\" data-mce-fragment=\"1\"\u003eHow should I take this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cem\u003eOral:\u003c\/em\u003e Take 45mg twice daily, 12 hours apart (in combination with Encorafenib) until disease progression or unacceptable toxicity.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cb\u003eHow to Take\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\"\u003e: MEKTOVI may be taken with or without food.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\"\u003e\u003cb\u003eNote:\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eConfirm BRAF V600 mutation status prior to treatment initiation. MEKTOVI (Binimetinib) is associated with a moderate or high emetic potential; antiemetics may be recommended to prevent nausea and vomiting.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #000000;\" data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"font-weight: 400; color: #000000;\"\u003eBefore starting MEKTOVI (Binimetinib) make sure to tell your doctor if you have any heart problems, high blood pressure, or a history of blood clots.  Also advise of any current or past history of eye problems, difficulty with breathing, liver or kidney problems.  For women, tell your doctor if you are pregnant or plan to become pregnant. MEKTOVI (Binimetinib) can harm your unborn baby. Women who are able to become pregnant should use effective birth control (contraception) during treatment with MEKTOVI (Binimetinib) and for at least 30 days after the final dose of MEKTOVI (Binimetinib).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #000000;\" data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eIf you forget or miss a dose, \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003edo not take a missed dose if \u0026lt;6 hours until the next dose. Do not take an additional dose if vomiting occurs after MEKTOVI (Binimetinib) administration; resume with the next scheduled dose.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #000000;\" data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"font-weight: 400; color: #000000;\"\u003eMEKTOVI (Binimetinib) should be stored at room temperature, 15 to 30 ˚C (59 to 86 ˚F). Protect from moisture.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #000000;\" data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-weight: 400;\" mce-data-marked=\"1\"\u003eF\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eatigue, nausea, diarrhea, vomiting, and abdominal pain. MEKTOVI (Binimetinib) has been associated with toxicities with heart failure, i\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003enterstitial pulmonary fibrosis, dermatological toxicity, ocular toxicity and thromboembolism.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #000000;\"\u003eNote this is not a complete list of side effects for MEKTOVI (Binimetinib), only common ones.\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"PFIZER","offers":[{"title":"15mg - 180 Tab - Canada - SPECIAL ORDER","offer_id":47138721661246,"sku":"","price":9898.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Mektovi.jpg?v=1695148801","url":"https:\/\/www.advochealth.com\/products\/mektovi-binimetinib","provider":"AdvocHealth","version":"1.0","type":"link"}