{"product_id":"nucala-mepolizumab","title":"NUCALA (Mepolizumab)","description":"\u003ch5\u003eWhat is this medication?\u003c\/h5\u003e\n\u003cp\u003e\u003cstrong\u003eNucala\u003c\/strong\u003e is a monoclonal antibody that works by reducing levels of eosinophils (a type of white blood cell). High eosinophil levels can contribute to certain disorders.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNucala\u003c\/strong\u003e is used together with other medicines to help control severe asthma in adults and children who are at least 6 years old. \u003cstrong\u003eNucala\u003c\/strong\u003e is not a rescue medicine for asthma attacks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNucala\u003c\/strong\u003e is used together with other medicines for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in adults whose disease is not controlled with nasal corticosteroids. \u003cstrong\u003eNucala\u003c\/strong\u003e helps reduce nasal congestion, nasal discharge, mucus in the throat, and loss of smell associated with CRSwNP, helps reduce the size of your nasal polyps and the use of oral corticosteroid medicines, and helps prevent surgery for your nasal polyps.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNucala \u003c\/strong\u003eis used in adults to help control symptoms and reduce flares of a rare autoimmune disorder called eosinophilic granulomatosis with polyangiitis (EPGA).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNucala \u003c\/strong\u003eis also used to help prevent flare-ups or reduce symptoms of high eosinophil levels (hypereosinophilic syndrome, or HES) in adults and children at least 12 years old.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNucala\u003c\/strong\u003e is given every four weeks by subcutaneous injection.\u003c\/p\u003e\n\u003ch5\u003eHow should I use this medication?\u003c\/h5\u003e\n\u003cp\u003e\u003cstrong\u003eNucala\u003c\/strong\u003e is not a rescue medicine for asthma attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your asthma medications are not working as well.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNucala\u003c\/strong\u003e is injected under the skin, usually once every 4 weeks. A healthcare provider may teach you how to properly use the medication by yourself. Follow all directions on your prescription label and read all medication guides or instruction sheets.\u003c\/p\u003e\n\u003cp\u003eYour doctor may perform blood tests to make sure you do not have conditions that would prevent you from safely using \u003cstrong\u003eNucala\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNucala\u003c\/strong\u003e powder must be mixed with a liquid (diluent) before using it. Read and carefully follow any Instructions for Use provided with your medicine. When using injections by yourself, be sure you understand how to properly mix and store the medicine.\u003c\/p\u003e\n\u003cp\u003eGently swirl but do not shake the mixed medicine. Prepare an injection only when you are ready to give it. Do not use \u003cstrong\u003eNucala\u003c\/strong\u003e if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.\u003c\/p\u003e\n\u003cp\u003eStore the vial (bottle) in its original carton at room temperature. Protect from light and do not freeze.\u003c\/p\u003e\n\u003cp\u003eStore the prefilled syringe or autoinjector in the original carton in a refrigerator. Do not freeze or shake the medicine. After removing the medicine from the carton, you must use the syringe or autoinjector within 8 hours.\u003c\/p\u003e\n\u003cp\u003eYou may store the prefilled syringe or autoinjector in the unopened carton at room temperature for up to 7 days. Throw away a syringe or autoinjector left out of the refrigerator for more than 7 days.\u003c\/p\u003e\n\u003cp\u003eEach vial, prefilled syringe, or autoinjector is for one use only. Throw it away after one use, even if there is still medicine left inside.\u003c\/p\u003e\n\u003cp\u003eUse a needle and syringe only once and then place them in a puncture-proof \"sharps\" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eDosing information:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eUsual Adult Dose for Asthma - Maintenance:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e100 mg subcutaneously every 4 weeks\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eUse: Add-on maintenance treatment of severe asthma with an eosinophilic phenotype\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComments:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThis drug should be administered in the upper arm, thigh, or abdomen.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eUsual Adult Dose for Chronic Rhinosinusitis with Nasal Polyps:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e100 mg subcutaneously every 4 weeks.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eUse: Add-on maintenance treatment of adult patients 18 years and older with chronic rhinosinusitis with nasal polyps (CRSwNP)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComments:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e-This drug should be administered in the upper arm, thigh, or abdomen.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eUsual Adult Dose for Eosinophilic Granulomatosis with Polyangiitis (EGPA):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e300 mg (as 3 separate 100 mg injections) subcutaneously every 4 weeks\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eComments:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThis drug should be administered in the upper arm, thigh, or abdomen as 3 separate 100 mg injections at least 5 cm (approximately 2 inches) apart if more than 1 injection is administered at the same site.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eUse: For eosinophilic granulomatosis with polyangiitis (EGPA)\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eUsual Adult Dose for Hypereosinophilic Syndrome (HES):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e300 mg (as 3 separate 100 mg injections) subcutaneously every 4 weeks\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eUse: treatment of hypereosinophilic syndrome (HES) for ≥6 months without an identifiable non-hematologic secondary cause.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComments\u003c\/strong\u003e:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThis drug should be administered in the upper arm, thigh, or abdomen as 3 separate 100 mg injections at least 5 cm (approximately 2 inches) apart if more than 1 injection is administered at the same site.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eUsual Pediatric Dose for Asthma - Maintenance:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e6 to 11 years:\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"padding-left: 60px;\"\u003e40 mg subcutaneously every 4 weeks\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e12 years or older:\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"padding-left: 60px;\"\u003e100 mg subcutaneously every 4 weeks\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComments\u003c\/strong\u003e:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThis drug should be administered in the upper arm, thigh, or abdomen.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eUse: Add-on maintenance therapy for severe asthma with an eosinophilic phenotype in children 6 years and older\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComments\u003c\/strong\u003e:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThis drug should be administered in the upper arm, thigh, or abdomen.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eUsual Pediatric Dose for Hypereosinophilic Syndrome (HES):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e300 mg (as 3 separate 100 mg injections) subcutaneously every 4 weeks\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eUse: treatment of pediatric patients aged 12 years and older with hypereosinophilic syndrome (HES) for ≥6 months without an identifiable non-hematologic secondary cause\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComments\u003c\/strong\u003e:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThis drug should be administered in the upper arm, thigh, or abdomen as 3 separate 100 mg injections at least 5 cm (approximately 2 inches) apart if more than 1 injection is administered at the same site.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eWhat if I miss a dose?\u003c\/h5\u003e\n\u003cp\u003eUse the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.\u003c\/p\u003e\n\u003ch5\u003eHow should I store this medication?\u003c\/h5\u003e\n\u003cp\u003eStore the vial (bottle) in its original carton at room temperature. Protect from light and do not freeze.\u003c\/p\u003e\n\u003cp\u003eStore the prefilled syringe or autoinjector in the original carton in a refrigerator. Do not freeze or shake the medicine. After removing the medicine from the carton, you must use the syringe or autoinjector within 8 hours.\u003c\/p\u003e\n\u003cp\u003eYou may store the prefilled syringe or autoinjector in the unopened carton at room temperature for up to 7 days. Throw away a syringe or autoinjector left out of the refrigerator for more than 7 days.\u003c\/p\u003e\n\u003ch5\u003eWhat should I avoid while using Nucala?\u003c\/h5\u003e\n\u003cp\u003eFollow your doctor's instructions about any restrictions on food, beverages, or activity.\u003c\/p\u003e\n\u003ch5\u003eWhat are the possible side effects of using this medication?\u003c\/h5\u003e\n\u003cp\u003eGet emergency medical help if you have signs of an allergic reaction to \u003cstrong\u003eNucala\u003c\/strong\u003e: hives, rash; wheezing, chest tightness, difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.\u003c\/p\u003e\n\u003cp\u003eCall your doctor at once if you have:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eunusual pain or tiredness;\u003c\/li\u003e\n\u003cli\u003eburning or tingling anywhere in your body; or\u003c\/li\u003e\n\u003cli\u003ea red or blistering skin rash.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCommon \u003cstrong\u003eNucala\u003c\/strong\u003e side effects may include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eheadache;\u003c\/li\u003e\n\u003cli\u003efeeling tired;\u003c\/li\u003e\n\u003cli\u003eback pain; or\u003c\/li\u003e\n\u003cli\u003epain, swelling, redness, burning, or itching where the medicine was injected.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\u003c\/p\u003e\n\u003ch5\u003eWhat other drugs will affect Nucala?\u003c\/h5\u003e\n\u003cp\u003eTell your doctor about all your current medicines and any you start or stop using, especially:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ean oral (taken by mouth) or inhaled steroid medicine.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eOther drugs may interact with mepolizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.\u003c\/p\u003e","brand":"GLAXO-SMITH KLINE","offers":[{"title":"100mg\/ml - Vial - Canada","offer_id":47259526267198,"sku":"","price":2262.0,"currency_code":"USD","in_stock":true},{"title":"100mg\/ml - 1x1ml Auto-Injector - Canada - SPECIAL ORDER","offer_id":47259526332734,"sku":"","price":2410.0,"currency_code":"USD","in_stock":true},{"title":"100mg\/ml - 1x1ml Pre-Filled Syringe - Canada - SPECIAL ORDER","offer_id":47259526365502,"sku":"","price":2410.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/files\/Nucalapen.jpg?v=1697230032","url":"https:\/\/www.advochealth.com\/products\/nucala-mepolizumab","provider":"AdvocHealth","version":"1.0","type":"link"}