{"product_id":"oracea-doxycycline","title":"ORACEA\/APPRILON (Doxycycline)","description":"\u003ch5\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eORACEA\/APPRILON (Doxycycline)\u003c\/strong\u003e\u003cbr\u003eAntibiotic, Tetracycline Derivative.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #ff6737;\"\u003eBrand Name US: Oracea\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"color: #ff6737;\"\u003eCanadian Equivalent: Apprilon\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eORACEA\/APPRILON (Doxycycline) officially indicated as an antibiotic for various bacterial infections. It is sometimes used off-label for post tendon repair surgery.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow does this medication work? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan data-mce-fragment=\"1\"\u003eDoxycycline inhibits protein synthesis by binding with the 30S and possibly the 50S ribosomal subunit(s) of susceptible bacteria; may also cause alterations in the cytoplasmic membrane.  Doxycycline also inhibits matrix metalloproteinases (MMP) activity which is elevated after a tendon tear\/rupture.  Doxycycline has been shown to accelerate tendon repair and improve the biomechanical properties of tendon, especially when paired with surgical management.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cstrong\u003ePost Tendon Repair Surgery\u003cbr\u003e\u003c\/strong\u003e\u003cem\u003eOral:\u003c\/em\u003e Take as directed by medical doctor; never exceed the maximum recommended daily dose.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eHow Do You Use\u003c\/b\u003e\u003cb\u003e\u003cspan\u003e \u003c\/span\u003eDoxycycline\u003c\/b\u003e\u003cb\u003e:\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003e\u003cspan\u003eTake doxycycline with food to reduce gastrointestinal symptoms.  Take with a full glass of water and do not lie down for at least 30 minutes after taking to reduce the risk of esophageal irritation and ulceration.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eIs Doxycycline Safe to Use During Pregnancy:\u003c\/b\u003e\u003cspan\u003e Doxycycline is unlikely to cause any significant teratogenic risk, but the available date is insufficient to say that there is no risk.   However, tetracyclines as a class should generally be considered a second-line antibiotic in pregnant women and their use should be avoided.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eCan cause esophagitis and ulcerations\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDiscontinue use in patients who experience a hypersensitivity syndrome, renal impairment, intracranial hypertension\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCan cause photosensitivity and tissue hyperpigmentation\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan data-mce-fragment=\"1\"\u003eIf you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light.  Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eWell tolerated, most side effects are transient and mild to moderate in nature. The most common side effects include:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e1-10%\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cem\u003eCardiovascular:\u003c\/em\u003e Hypertension (3%)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cem\u003eCentral nervous system:\u003c\/em\u003e Anxiety (2%), pain (2%)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cem\u003eEndocrine \u0026amp; Metabolic:\u003c\/em\u003e Increased lactate dehydrogenase (2%), increased serum glucose (1%)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cem\u003eGastrointestinal:\u003c\/em\u003e Diarrhea (5%), upper abdominal pain (2%), abdominal distention (1%), abdominal pain (1%), xerostomia (1%)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cem\u003eHepatic:\u003c\/em\u003e Increased serum aspartate aminotransferase (2%)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cem\u003eInfection:\u003c\/em\u003e Fungal infection (2%), influenza (2%)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cem\u003eNeuromuscular \u0026amp; skeletal:\u003c\/em\u003e Back pain (1%)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cem\u003eRespiratory:\u003c\/em\u003e Nasopharyngitis (5%), sinusitis (3%), nasal congestion (2%), sinus headache (1%)\u003c\/span\u003e\u003c\/p\u003e","brand":"GALDERMA","offers":[{"title":"40mg - 28 Cap - Canada","offer_id":47139258368318,"sku":null,"price":564.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Apprilon.jpg?v=1695150835","url":"https:\/\/www.advochealth.com\/products\/oracea-doxycycline","provider":"AdvocHealth","version":"1.0","type":"link"}