{"product_id":"otezla-apremilast","title":"OTEZLA (Apremilast) - Ships From Canada","description":"\u003ch5 data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cb data-mce-fragment=\"1\"\u003eOTEZLA (Apremilast)\u003cbr\u003e\u003c\/b\u003e\u003cspan data-mce-fragment=\"1\"\u003ePhosphodiesterase-4 Enzyme Inhibitor\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eOTEZLA (Apremilast)\u003cspan data-mce-fragment=\"1\" style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\"\u003e is an inhibitor of phosphodiesterase 4 (PDE4) and is used for the  treatment of active psoriatic arthritis and moderate to severe plaque psoriasis.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003eHow does this medication work?\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eOTEZLA (Apremilast) is an \u003c\/span\u003e\u003cspan\u003einhibitor of phosphodiesterase 4 (PDE4) and works intracellularly to modulate a network of pro-inflammatory and anti-inflammatory mediators.  Phosphodiesterase 4 inhibition elevates intracellular cAMP levels, thereby reducing the inflammatory response by modulating the expression of tumor necrosis factor-α (TNF-α), interleukin-23 (IL-23), IL-17 and IL-10.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cstrong\u003eBechet Disease\u003cbr\u003e\u003c\/strong\u003e\u003cspan\u003e\u003cem\u003eOral:\u003c\/em\u003e Take 10 mg in the morning on day 1. Titrate upward by additional 10 mg per day on days 2 to 5 as follows: Day 2: 10 mg twice daily; Day 3: 10 mg in the morning and 20 mg in the evening; Day 4: 20 mg twice daily; Day 5: 20 mg in the morning and 30 mg in the evening. Maintenance dose: 30 mg twice daily starting on day 6.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePsoriasis\u003cbr\u003e\u003c\/strong\u003e\u003cspan\u003e\u003cem\u003eOral:\u003c\/em\u003e Take 10 mg in the morning on day 1. Titrate upward by additional 10 mg per day on days 2 to 5 as follows: Day 2: 10 mg twice daily; Day 3: 10 mg in the morning and 20 mg in the evening; Day 4: 20 mg twice daily; Day 5: 20 mg in the morning and 30 mg in the evening. Maintenance dose: 30 mg twice daily starting on day 6.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePsoriatic Arthritis\u003cbr\u003e\u003c\/strong\u003e\u003cspan\u003e\u003cem\u003eOral:\u003c\/em\u003e Take 10 mg in the morning on day 1. Titrate upward by additional 10 mg per day on days 2 to 5 as follows: Day 2: 10 mg twice daily; Day 3: 10 mg in the morning and 20 mg in the evening; Day 4: 20 mg twice daily; Day 5: 20 mg in the morning and 30 mg in the evening. Maintenance dose: 30 mg twice daily starting on day 6.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cb\u003eHow to Take:\u003c\/b\u003e Can be taken with\/without food.  Do not crush, chew, or split the tablets.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBefore starting OTEZLA (Apremilast), make sure your physician is aware of any allergies or medications you currently take. Apremilast, use has been associated with several adverse effects including diarrhea, nausea, and vomiting.  Consider reducing the dose or holding Apremilast if you develop severe diarrhea, nausea, or vomiting.  Apremilast should be used with caution if you have a history of depression and\/or suicidal thoughts. Apremilast may cause weight loss, monitor weight regularly. Discontinuation of therapy should be considered with unexplained or significant weight loss.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eIf you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eDiarrhea, nausea, headache, weight loss, decreased appetite, dyspepsia, gastroesophageal reflux disease, cough, rash.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eNote this is not a complete list of side effects for OTEZLA (Apremilast), only common ones.\u003c\/span\u003e\u003c\/p\u003e","brand":"AMGEN","offers":[{"title":"30mg - 56 Tab - Canada","offer_id":47139267346750,"sku":null,"price":2961.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Otezla.jpg?v=1695150861","url":"https:\/\/www.advochealth.com\/products\/otezla-apremilast","provider":"AdvocHealth","version":"1.0","type":"link"}