{"product_id":"prezcobix-darunavir-cobicistat","title":"PREZCOBIX (Darunavir\/Cobicistat)","description":"\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat is this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cb\u003ePREZCOBIX (Darunavir\/Cobicistat)\u003cbr\u003e\u003c\/b\u003e\u003cspan\u003eProtease Inhibitor\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003ePREZCOBIX (Darunavir\/Cobicistat) is indicated for treatment of HIV-1 Infection.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cb\u003eALERT: WARNING\u003cbr\u003e\u003c\/b\u003e\u003cspan\u003eThe National Institutes of Health’s COVID-19 guidelines recommend against the use of HIV protease inhibitors, such as darunavir and cobicistat for the treatment of COVID-19.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow does this medication work? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003ePREZCOBIX (Darunavir\/Cobicistat) is a two-drug combination of darunavir and cobicistat.  Darunavir binds to HIV-1 protease and inhibits cleavage of viral Gag-Pol polyprotein precursors into individual functional proteins required for infectious HIV. This results in the formation of immature, non-infectious viral particles. Cobicistat is a cytochrome P450 3A inhibitor which will increase the systemic concentration of darunavir.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003ci\u003e\u003cspan\u003eOral: \u003c\/span\u003e\u003c\/i\u003e\u003cspan\u003e Take one tablet (darunavir 800mg\/cobicistat 150mg) once daily on combination with other antiretrovirals.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cb\u003eNote:\u003c\/b\u003e Genotype testing is advised prior to therapy initiation in antiretroviral treatment-experienced patients; if testing is not feasible, use is recommended in protease-inhibitor naïve patients only.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDo not use darunavir\/cobicistat in combination with abacavir and lamivudine in patients with a pre-antiretroviral therapy HIV RNA ≥100,000 copies\/mL.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cb\u003eHow to Take\u003c\/b\u003e\u003cb\u003e:\u003c\/b\u003e Take with food.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eBefore starting PREZCOBIX (Darunavir\/Cobicistat)\u003c\/span\u003e\u003cspan\u003e make sure your physician is aware of any allergies or medications you currently take, and activities you perform. PREZCOBIX (Darunavir\/Cobicistat)\u003c\/span\u003e\u003cspan\u003e may cause redistribution of fat, liver injury and renal toxicity, immune reconstitution syndrome, hypersensitivity reactions, including rash, anaphylaxis, erythema multiforme, Stevens-Johnson syndrome (rare) and toxic epidermal necrolysis. PREZCOBIX (Darunavir\/Cobicistat) should be used with caution in patients with diabetes, hemophilia A or B and hepatic impairment.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eIf you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eImmune reconstitution syndrome\u003cbr\u003e\u003c\/span\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003cspan\u003eNote this is not a complete list of side effects for PREZCOBIX (Darunavir\/Cobicistat), only the most common.\u003c\/span\u003e\u003c\/p\u003e","brand":"JANSSEN","offers":[{"title":"800mg\/150mg - 30 Tab - Canada","offer_id":47139887808830,"sku":null,"price":1653.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Prezcobix.jpg?v=1695153553","url":"https:\/\/www.advochealth.com\/products\/prezcobix-darunavir-cobicistat","provider":"AdvocHealth","version":"1.0","type":"link"}