{"product_id":"prograf-tacrolimus","title":"PROGRAF (Tacrolimus)","description":"\u003ch5 data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTacrolimus, Advagraf\/Astragraf\/Envarsus\/Prograf\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003eCalcineurin Inhibitor\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #404040;\"\u003e\u003cb data-mce-fragment=\"1\"\u003e“ALERT: US Boxed Warning\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #404040;\"\u003e\u003cb data-mce-fragment=\"1\"\u003eMalignancies and serious infection:\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/b\u003eIncreased risk for developing serious infections and malignancies with tacrolimus or other immunosuppressants that may lead to hospitalization or death.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #404040;\"\u003e\u003cb data-mce-fragment=\"1\"\u003eMortality in liver transplantation (Astagraf XL):\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/b\u003eIncreased mortality in female transplant patients with Astagraf XL. Astagraf XL is not approved for use in liver transplantation.”\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eOfficially indicated for organ rejection prophylaxis. It is also prescribed off-label for use in Crohn disease (perianal\/fistulizing disease), graft-versus host disease (prevention\/treatment), immunosuppression (maintenance) after lung transplant, intestinal transplant, myasthenia gravis, rheumatoid arthritis (refractory), and peripheral nerve regeneration.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow does this medication work? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eTacrolimus sup\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003epresses cellular immunity (inhibits T-lymphocyte activation), by binding to an intracellular protein, FKBP-12, and complexes with calcineurin dependent proteins to inhibit calcineurin phosphatase activity. Inhibition of calcineurin also is important in maintaining neuronal and synaptic integrity and homeostasis for peripheral nerve regeneration.  \u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003eHow should I take this medication?\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eImmunosuppressants such as tacrolimus have a wide range of dosing options. For a comprehensive listing, please check an official drug monograph. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cul data-mce-fragment=\"1\"\u003e\n\u003cli data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eDo not use in patients with a known hypersensitivity to tacrolimus.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eDo not use in patients with congenital long QT syndrome\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eUse with caution in patient with heart failure, brady arrhythmia, taking antiarrhythmic mediations or other drugs that can lead to QT prolongation\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eImmunosuppressant agents including tacrolimus can increase the risk of infection leading to hospitalization or death\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eImmunosuppressive agents including tacrolimus may be associated with the development of malignancies that can lead to hospitalization or death\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eIf you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eImmunosuppressants such as tacrolimus have an extensive side effect profile. For a comprehensive listing, please check an official drug monograph.\u003c\/span\u003e\u003c\/p\u003e","brand":"ASTELLAS PHARMA","offers":[{"title":"0.5mg - 100 Cap - Canada","offer_id":47139884138814,"sku":null,"price":249.0,"currency_code":"USD","in_stock":true},{"title":"1mg - 100 Cap - Canada","offer_id":47139884204350,"sku":null,"price":505.0,"currency_code":"USD","in_stock":true},{"title":"5mg - 100 Cap - Canada","offer_id":47139884269886,"sku":null,"price":2442.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Prograf0.5mg.jpg?v=1695153547","url":"https:\/\/www.advochealth.com\/products\/prograf-tacrolimus","provider":"AdvocHealth","version":"1.0","type":"link"}