{"product_id":"protopic-tacrolimus","title":"PROTOPIC (Tacrolimus)","description":"\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003ePROTOPIC (Tacrolimus)\u003c\/strong\u003e\u003cbr\u003eCalcineurin Inhibitor, Immunosuppressant\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePROTOPIC (Tacrolimus) is officially indicated for the treatment of atopic dermatitis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eALERT: WARNING\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eMalignancy:\u003c\/b\u003e\u003cspan\u003e \u003cbr\u003eAlthough a causal relationship has not been established, rare cases of malignancy (ie, skin cancer and lymphoma) have been reported in patients treated with topical calcineurin inhibitors, including tacrolimus ointment. Avoid continuous long-term use of topical calcineurin inhibitors, including tacrolimus ointment, in any age group, and limit application to areas of involvement with atopic dermatitis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePediatrics:\u003c\/b\u003e\u003cspan\u003e Tacrolimus ointment is not indicated for use in children younger than 2 years of age. Only tacrolimus 0.03% ointment is indicated for use in children 2 to 15 years of age.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow does this medication work? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003ePROTOPIC (Tacrolimus) suppresses cellular immunity (inhibits T-lymphocyte activation), by binding to an intracellular protein, FKBP-12, and complexes with calcineurin dependent proteins to inhibit calcineurin phosphatase activity.\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cstrong\u003eAtopic dermatitis (moderate-to-severe)\u003cbr\u003e\u003c\/strong\u003e\u003cem\u003eTopical:\u003c\/em\u003e Apply thin layer of 0.03% or 0.1% ointment to affected area twice daily; rub in gently and completely.  Discontinue use when symptoms have cleared. If no improvement within 6 weeks, patients should be re-examined to confirm diagnosis.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cb\u003eHow to Use Topical Tacrolimus, Protopic:\u003c\/b\u003e  Apply a thin layer to the affected area twice daily.  Do not cover the areas with an occlusive dressing.  A local sensation of burning and redness is very commonly experienced during the first days to week when using Tacrolimus, Protopic.  Stop using when symptoms resolve and\/or re-evaluate if symptoms still persist beyond 6 weeks. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eHigher risk of developing \u003c\/span\u003e\u003cspan\u003eeczema herpeticum, varicella zoster, and herpes simplex\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAssociated with the development of lymphadenopathy, malignancy, skin papilloma\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDo not use in immunocompromised patients\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\" data-mce-fragment=\"1\"\u003eIf you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\" data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light, heat, and moisture. Keep the tube tightly closed. Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eThe most common adverse reactions when using Tacrolimus, Protopic\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eare associated with the central nervous system and the skin, specifically at the sites of application:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCentral nervous system: Headache (adults 19% to 20%), tingling of skin (2% to 8%), hyperesthesia (adults 3% to 7%), insomnia (adults 4%), paresthesia (adults 3%), depression (adults 2%), pain (1% to 2%)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDermatologic: Burning sensation of skin (43% to 58%), pruritus (41% to 46%), erythema (25% to 28%), skin infection (adults 12%), acne vulgaris (adults 4% to 7%), urticaria (adults 3% to 6%), folliculitis (2% to 6%), skin rash (adults 2% to 5%), dermatological disease (children 4%), vesiculobullous dermatitis (children 4%), contact dermatitis (3% to 4%), pustular rash (adults 2% to 4%), contact eczema herpeticum (children 2%), fungal dermatitis (adults 1% to 2%), sunburn (adults 1% to 2%), alopecia.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNote this is not a complete list of side effects for PROTOPIC (Tacrolimus), only common ones.\u003c\/span\u003e\u003c\/p\u003e","brand":"LEO PHARMA INC","offers":[{"title":"0.1% Ointment - 30g - Canada","offer_id":47139894100286,"sku":null,"price":214.0,"currency_code":"USD","in_stock":true},{"title":"0.1% Ointment - 60g - Canada","offer_id":47140180525374,"sku":"","price":423.0,"currency_code":"USD","in_stock":true},{"title":"0.03% Ointment - 30g - Canada","offer_id":47139894067518,"sku":null,"price":217.0,"currency_code":"USD","in_stock":true},{"title":"0.03% Ointment - 60g - Canada","offer_id":47140180492606,"sku":"","price":423.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Protopic0.1.jpg?v=1695153582","url":"https:\/\/www.advochealth.com\/products\/protopic-tacrolimus","provider":"AdvocHealth","version":"1.0","type":"link"}