{"product_id":"tagrisso-osimertinib","title":"TAGRISSO (Osimertinib)","description":"\u003ch5 data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cb\u003eTAGRISSO (Osimertinib)\u003cbr\u003e\u003c\/b\u003e\u003cspan\u003eAntineoplastic Agent, Epidermal Growth Factor Receptor (EGFR) Inhibitor\u003c\/span\u003e\u003cspan\u003e;\u003c\/span\u003e\u003cspan\u003e Tyrosine Kinase Inhibitor\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eTAGRISSO (Osimertinib) is indicated for treatment of non-small cell lung cancer; metastatic.\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003eHow does this medication work?\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eTAGRISSO (Osimertinib) is an irreversible Epidermal Growth Factor Receptor (EGRF) Inhibitor in addition to inhibiting tyrosine kinase autophosphorylation \u003c\/span\u003e\u003cspan\u003eand thus blocking the activity of downstream signaling pathways related to growth and apoptosis suppression.  \u003c\/span\u003e\u003cspan\u003eIt\u003c\/span\u003e\u003cspan\u003e binds to select mutant forms of EGFR, including T790M, L858R, and exon 19 deletion at lower concentrations than wild-type. Osimertinib exhibits less activity against wild-type EGFR (as compared to other EGFR inhibitors) and is selective for sensitizing mutations and the T790M resistance mutation, which is the most common mechanism of resistance to EGFR tyrosine kinase inhibitors\u003c\/span\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003e\u003cem\u003eOral:\u003c\/em\u003e Take 80 mg once daily until disease progression or unacceptable toxicity.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eHow to Take:\u003c\/b\u003e\u003cspan\u003e May be administered with or without food.  For patients who have difficulty swallowing tablets, disperse tablet in 60 mL of noncarbonated water (only), stir until tablet is dispersed into small pieces (will not dissolve completely) and immediately swallow. Rinse container with 120 to 240 mL of water and immediately drink). \u003c\/span\u003eDo not crush, heat, or ultrasonicate during preparation of solution. \u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eTAGRISSO (Osimertinib) can increase the risk of experiencing torsade de pointes during treatment with a QTc-prolonging drug.  Contact your physician or pharmacist immediately if you experience symptoms of chest pain or discomfort, changes in heartbeat, palpitations, dizziness, light-headedness, fainting or changes in or new use of medications.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIf you have any cardiac risk factors and conditions that can affect left ventricular ejection fraction (LVEF), cardiac monitoring, including an assessment of LVEF at baseline and during treatment, should be considered.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIf a dose of TAGRISSO (Osimertinib) is missed, make up the dose unless the next dose is due within 12 hours.\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e Do not take double or extra doses.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eSkin rash, xeroderma, nail disease, pruritis, hypermagnesemia, hypokalemia, diarrhea, stomatitis, decreased appetite, constipation, nausea, vomiting, lymphocytopenia, anemia, thrombocytopenia, neutropenia, increased serum aspartate aminotransferase, increased serum alanine aminotransferase, hyperbilirubinemia, fatigue, headache, cough, dyspnea.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNote this is not a complete list of side effects for TAGRISSO (Osimertinib), only \u003c\/span\u003e\u003cspan\u003ecommon ones.\u003c\/span\u003e\u003c\/p\u003e","brand":"ASTRAZENECA","offers":[{"title":"40mg - 30 Tab - Canada - SPECIAL ORDER","offer_id":47149354189118,"sku":null,"price":32531.0,"currency_code":"USD","in_stock":true},{"title":"80mg - 30 Tab - Canada - SPECIAL ORDER","offer_id":47149354221886,"sku":null,"price":32531.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Tagrisso40mg.jpg?v=1695211057","url":"https:\/\/www.advochealth.com\/products\/tagrisso-osimertinib","provider":"AdvocHealth","version":"1.0","type":"link"}