{"product_id":"vizimpro-dacomitinib","title":"VIZIMPRO (Dacomitinib)","description":"\u003ch5 data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong\u003eVIZIMPRO (Dacomitinib)\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eAntineoplastic Agent, Epidermal Growth Factor Receptor (EGFR) Inhibitor, Tyrosine Kinase Inhibitor\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eVIZIMPRO (Dacomitinib) is indicated for the treatment of non-small cell lung cancer.\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003eHow does this medication work?\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eVIZIMPRO (Dacomitinib) \u003c\/span\u003e\u003cspan\u003eis an irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor which has activity against EGFR\/HER1, HER2, and HER4, as well as some EGFR-activating mutations (exon 19 deletion or exon 21 L858R substitution mutation). \u003c\/span\u003e\u003cspan\u003eDacomitinib displays antitumor activity against by inhibiting autophosphorylation against HER family targets including mutated EGFR.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003e\u003cem\u003eOral:\u003c\/em\u003e Take 45mg once daily.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eHow to Take:\u003c\/strong\u003e Take at the same time each day with or without food. Avoid the concomitant use of proton pump inhibitors with dacomitinib. If using an H2 blocker or antacid, administer Dacomitinib at least 6 hours before or 10 hours after the H2 blocker or antacid.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eBefore starting VIZIMPRO (Dacomitinib) make sure your physician is aware of any allergies or medications you currently take.  Dacomitinib causes dermatologic toxicity, gastrointestinal toxicity and pulmonary toxicity.  Prior to using Dacomitinib confirm t\u003c\/span\u003e\u003cspan\u003ehe presence of epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 L858R mutations in tumor specimen prior to therapy initiation.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eIf a dose is missed or vomited, do not make up the missed\/vomited dose; administer the next dose as scheduled.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eChest pain, insomnia, skin rash, paronychia, xeroderma, alopecia, pruritis, dermatitis, electrolyte disturbances (i.e. hypocalcemia, hypokalemia, hyponatremia, hypomagnesemia), hyperglycemia, hypoalbuminemia, diarrhea, stomatitis, nausea, constipation, oral mucosa ulcer, anemia, lymphocytopenia, elevated liver enzymes, conjunctivitis, cough, dyspnea, upper respiratory tract infection.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNote this is not a complete list of side effects for VIZIMPRO (Dacomitinib), only common ones.\u003c\/span\u003e\u003c\/p\u003e","brand":"PFIZER","offers":[{"title":"15mg - 30 Tab - Canada","offer_id":47160627331390,"sku":null,"price":10462.0,"currency_code":"USD","in_stock":true},{"title":"30mg - 30 Tab - Canada","offer_id":47160627364158,"sku":null,"price":10462.0,"currency_code":"USD","in_stock":true},{"title":"45mg - 30 Tab - Canada","offer_id":47160627396926,"sku":null,"price":10462.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Vizimpro15mg.png?v=1695298073","url":"https:\/\/www.advochealth.com\/products\/vizimpro-dacomitinib","provider":"AdvocHealth","version":"1.0","type":"link"}