{"product_id":"xalkori-crizotinib","title":"XALKORI (Crizotinib)","description":"\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cstrong\u003eXALKORI (Crizotinib)\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eAntineoplastic Agent, Anaplastic Lymphoma Kinase Inhibitor; Tyrosine Kinase Inhibitor\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eXALKORI (Crizotinib) is indicated for the treatment of non-small cell lung cancer.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow does this medication work? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eCrizotinib is \u003c\/span\u003e\u003cspan\u003eis a tyrosine kinase receptor inhibitor which inhibits anaplastic lymphoma kinase (ALK), Hepatocyte Growth Factor Receptor (HGFR, c-MET), ROS1 (c-ros), and Recepteur d’Origine Nantais (RON) which reduces proliferation of genetically altered cells.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003ci data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eOral:\u003c\/span\u003e\u003c\/i\u003e\u003cspan data-mce-fragment=\"1\"\u003e Take 250mg twice daily.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong\u003eHow to Take:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003eSwallow the capsule whole; do not crush, chew or open the capsule.  Take with or without food. \u003cspan data-mce-fragment=\"1\" style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\"\u003eDo not drink grapefruit juice, eat grapefruit or take supplements containing grapefruit extract during treatment with XALKORI (Crizotinib). \u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eBefore starting XALKORI (Crizotinib) make sure your physician is aware of any allergies or medications you currently take.  Crizotinib can cause bradycardia and as a result, regular heart rate and blood pressure monitoring is important to avoid life-threatening bradycardia.  Crizotinib has been reported to cause gastrointestinal toxicity, hepatotoxicity, ocular toxicity (i.e. \u003c\/span\u003e\u003cspan\u003eblurred vision, diplopia, photophobia, photopsia, visual acuity decreased, visual brightness, visual field defect, visual impairment, and\/or vitreous floaters), pulmonary toxicity, QT prolongation, hepatic and renal impairment.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eIf you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eEdema, pulmonary embolism, bradycardia, fatigue, neuropathy, headache, dizziness, skin rash, hypophosphatemia, hypokalemia, diarrhea, nausea, vomiting, constipation, abdominal pain, dyspepsia, hematologic disturbances (i.e. neutropenia, lymphocytopenia), limb pain, visual disturbances, upper respiratory track infections, fever, muscle spasm and renal cysts.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNote this is not a complete list of side effects for XALKORI (Crizotinib), only common ones.\u003c\/span\u003e\u003c\/p\u003e","brand":"PFIZER","offers":[{"title":"200mg - 60 Cap - Canada","offer_id":47160893636926,"sku":null,"price":14221.0,"currency_code":"USD","in_stock":true},{"title":"250mg - 60 Cap - Canada","offer_id":47160893669694,"sku":null,"price":14221.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Xalkori200mg.jpg?v=1695299179","url":"https:\/\/www.advochealth.com\/products\/xalkori-crizotinib","provider":"AdvocHealth","version":"1.0","type":"link"}