{"product_id":"xeljanz-xr-tofacitinib","title":"XELJANZ XR (Tofacitinib)","description":"\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTofacitinib, Xeljanz, Xeljanz XR\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eAntirheumatic, Disease Modifying;\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003eJanus Associated Kinase Inhibitor\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eTofacitinib, Xeljanz is officially indicated for psoriatic arthritis, rheumatoid arthritis, ulcerative colitis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cb data-mce-fragment=\"1\"\u003e“Alert: Black Box Warning\u003c\/b\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cb data-mce-fragment=\"1\"\u003eSerious infections:\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/b\u003ePatients treated with tofacitinib are at increased risk of developing serious infections such as tuberculosis, fungal infections (i.e. cryptococcosis, pneumocystosis), herpes zoster, that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosuppressants, such as methotrexate or corticosteroids.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eIf a serious infection develops, interrupt tofacitinib until the infection is controlled.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cb data-mce-fragment=\"1\"\u003eMalignancies:\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/b\u003eLymphoma and other malignancies have been observed in patients treated with tofacitinib. Epstein-Barr virus-associated posttransplant lymphoproliferative disorder has been observed at an increased rate in renal transplant patients treated with tofacitinib and concomitant immunosuppressive medications.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cb data-mce-fragment=\"1\"\u003eThrombosis:\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/b\u003eThrombosis, including pulmonary embolism, deep venous thrombosis, and arterial thrombosis, has occurred in patients treated with tofacitinib and other Janus kinase inhibitors used to treat inflammatory conditions.  Avoid tofacitinib in patients at risk. Discontinue tofacitinib and promptly evaluate patients with symptoms of thrombosis.”\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow does this medication work? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eTofacitinib, Xeljanz\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003einhibits Janus kinase (JAK) enzymes, which are intracellular enzymes which are involved in cytokine signaling as well phosphorylate signal transducers known as activators of transcription (STATs) which regulate gene expression and intracellular activity. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003e\u003cem\u003eExtended Release:\u003c\/em\u003e 11mg once daily.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cb data-mce-fragment=\"1\"\u003eHow to Take:\u003c\/b\u003e The tablet can be taken with or without food.  In the case of extended release tablets, swallow the tablet whole; do not crush, split, or chew.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eBefore starting make sure your physician is aware of any allergies or medications you currently take, there is a risk of bone marrow suppression, GI perforation, and hepatic impairment.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat if I miss a dose?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eIf you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication? \u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eInfection, nasopharyngitis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eNote this is not a complete list of side effects for \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003eTofacitinib, Xeljanz\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003eonly common ones.\u003c\/span\u003e\u003c\/p\u003e","brand":"PFIZER","offers":[{"title":"11mg - 30 Tab - Canada","offer_id":47160889704766,"sku":null,"price":3802.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/files\/XeljanzXR11mg.jpg?v=1695674393","url":"https:\/\/www.advochealth.com\/products\/xeljanz-xr-tofacitinib","provider":"AdvocHealth","version":"1.0","type":"link"}