{"product_id":"xifaxan-zaxine-rifaximin","title":"XIFAXAN\/ZAXINE (Rifaximin)","description":"\u003ch5 data-mce-fragment=\"1\"\u003eWhat is this medication?\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong\u003eXIFAXAN\/ZAXINE (Rifaximin)\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eRifamycin\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #ff6737;\"\u003eBrand Name US: Xifaxan\u003cbr\u003eCanadian Equivalent: Zaxine\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eXIFAXAN\/ZAXINE (Rifaximin) is officially indicated to treat hepatic encephalopathy, irritable bowel syndrome without constipation, and traveler’s diarrhea.  It is also prescribed off-label for use in clostridioides difficile infection and small intestinal bacterial overgrowth (SIBO).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003eHow does this medication work?\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan\u003eXIFAXAN\/ZAXINE (Rifaximin) inhibits bacterial RNA synthesis by binding to bacterial DNA-dependent RNA polymerase.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I take this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cstrong\u003eClostridioides Difficile Infection (Second or Recurrent)\u003cbr\u003e\u003c\/strong\u003e\u003cspan\u003e\u003cem\u003eOral:\u003c\/em\u003e Take 400mg three times daily for 20 days; administer after taking a 10-day course of vancomycin.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHepatic Encephalopathy\u003cbr\u003e\u003c\/strong\u003e\u003cspan\u003e\u003cem\u003eOral:\u003c\/em\u003e Take 400mg three times daily or 550mg twice daily for 5 to 10 days.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIrritable Bowel Syndrome (without constipation)\u003cbr\u003e\u003c\/strong\u003e\u003cspan\u003e\u003cem\u003eOral:\u003c\/em\u003e Take 550mg three times daily for 14 days.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSmall Intestinal Bacterial Overgrowth (SIBO)\u003cbr\u003e\u003c\/strong\u003e\u003cspan\u003e\u003cem\u003eOral:\u003c\/em\u003e Take 550mg three times daily for 14 days.  \u003c\/span\u003e\u003cspan\u003eFor patients with methane-predominant bacterial overgrowth, some experts use rifaximin as part of an appropriate combination regimen.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTravellers Diarrhea\u003cbr\u003e\u003c\/strong\u003e\u003cspan\u003e\u003cem\u003eOral:\u003c\/em\u003e Take 200mg three times daily for 3 days.  Avoid in patients with fever or bloody diarrhea.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cb\u003eHow to Take: \u003c\/b\u003eCan be taken with or without food. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat should I watch for while using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003e\u003cspan style=\"font-weight: 400;\" data-mce-fragment=\"1\" data-mce-style=\"font-weight: 400;\"\u003eBefore starting XIFAXAN\/ZAXINE (Rifaximin), make sure your physician is aware of any allergies or medications you currently take\u003c\/span\u003e. \u003c\/span\u003eProlonged use may result in fungal or bacterial superinfection, including Clostridioides difficile-associated diarrhea (CDAD) and pseudomembranous colitis. Avoid using if you have diarrhea with fever and\/or blood in the stool.  You need to consider alternative therapy if symptoms persist or worsen after 1 to 2 days of treatment.  Use with caution in cases with severe hepatic impairment.\u003c\/p\u003e\n\u003ch5\u003eWhat if I miss a dose?\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eIf you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHow should I store this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eKeep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eWhat are the possible side effects of using this medication?\u003c\/span\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003e\u003c\/span\u003e\u003cspan\u003ePeripheral edema, d\u003c\/span\u003e\u003cspan\u003eizziness, fatigue, a\u003c\/span\u003e\u003cspan\u003escites, n\u003c\/span\u003e\u003cspan\u003eausea, irritable bowel syndrome with diarrhea.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eNote this is not a complete list of side effects for XIFAXAN\/ZAXINE (Rifaximin), only common ones.\u003c\/span\u003e\u003c\/p\u003e","brand":"SALIX PHARMACEUTICALS","offers":[{"title":"550mg - 60 Tab - Canada","offer_id":47160885543230,"sku":null,"price":2181.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0711\/0321\/7982\/products\/Xifaxan-Zaxine.jpg?v=1695299154","url":"https:\/\/www.advochealth.com\/products\/xifaxan-zaxine-rifaximin","provider":"AdvocHealth","version":"1.0","type":"link"}